The city of Puebla was founded on April 16, 1531 as "La Puebla de los Ángeles". It was the first city in central Mexico founded by the Spanish conquerors that was not built upon the ruins of a conquered Amerindian settlement. Its strategic location, half-way between the port of Veracruz and Mexico City, made it the second most important city during the colonial period. During the 17th century, Sor Juana Inés de la Cruz lived in the city until her confrontation with the Bishop of Puebla.

Four decades after Mexico's independence, General Ignacio Zaragoza's army defeated French expeditionary forces near Puebla on May 5, 1862 in the Battle of Puebla. It was after this battle that the name of the city was changed to "Heróica Puebla de Zaragoza".

In the late nineteenth and early twentieth centuries a number of European immigrants came to the city, mainly from Germany, Italy and Spain. Today, the Colonia Humboldt neighborhood shows the influence of the local German population in its architecture, traditions and festivals like the local Oktoberfest, as well as in the town of Chipilo, now absorbed by the metropolitan area of the city, where people speak a dialect of Venetian known as the Chipilo Venetian dialect. The folkloric Mexican women's dress known as China Poblana was created in Puebla. As well, the "Talavera Poblana" is a fine earthenware of colonial origin still made in the city. It's a unique motif to Puebla in general; dineware, plant pots, churches and even streets may be lined with tiles of Talavera.